| Identification | Back Directory | [Name]
(1R,2R)-trans-N-Boc-2-Aminocyclohexanol | [CAS]
155975-19-2 | [Synonyms]
172618
(1R,2R)-N-Boc-2-aminocyclohexanol
(1R,2R)-trans-N-Boc-2-Aminocyclohexanol
(1R,2R)-N-Boc-2-aminocyclohexanol,99%e.e.
1H-Inden-2-ol,1-amino-2,3-dihydro-,(1R,5S)-
tert-butyl N-[(1R,2R)-2-hydroxycyclohexyl]carbamate
(1R,2R)-trans-2-(N-tert-butyloxycarbonyl)amino-1-cyclohexanol
Carbamic acid, N-[(1R,2R)-2-hydroxycyclohexyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C11H21NO3 | [MDL Number]
MFCD11656036 | [MOL File]
155975-19-2.mol | [Molecular Weight]
215.29 |
| Chemical Properties | Back Directory | [Melting point ]
110 °C | [Boiling point ]
337.7±31.0 °C(Predicted) | [density ]
1.06±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
12.11±0.40(Predicted) | [Appearance]
White to off-white Solid | [Optical Rotation]
[α]/D +4.9±0.5°, c = 1 in chloroform | [BRN ]
6921870 |
| Hazard Information | Back Directory | [Synthesis]
Step B: Preparation of tert-butyl (1R,2R)-(2-hydroxycyclohexyl)carbamate
To a mixed solution of tert-butyl (1R,2R)-(2-benzyloxycyclohexyl)carbamate (7 g, 23 mmol) in ethyl acetate and methanol (80 mL, 9:1) was added 10% Pd-C catalyst (1.13 g). The hydrogenation reaction was carried out at 35 psi hydrogen pressure for 4 hours. Upon completion of the reaction, it was filtered through a diatomaceous earth pad to remove the catalyst. The filtrate was concentrated to give the target product (Cas:155975-19-2) as an oil (4.7 g, 95% yield). Mass spectrometry (MS) analysis: (M + 1): 215.95. | [References]
[1] Patent: US2007/287695, 2007, A1. Location in patent: Page/Page column 14; 55
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 1, p. 119 - 132 |
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