ChemicalBook--->CAS DataBase List--->15599-39-0

15599-39-0

15599-39-0 Structure

15599-39-0 Structure
IdentificationBack Directory
[Name]

noxytiolin
[CAS]

15599-39-0
[Synonyms]

Gynaflex
Noxyflex S
noxytiolin
Noxythiolin
Noxytioline
Noxythioline
1-(Hydroxymethyl)-3-methylthiourea
(methylamino-λsup4sup-sulfanylidyne)methylamino]methanol
[EINECS(EC#)]

239-679-5
[Molecular Formula]

C3H8N2OS
[MDL Number]

MFCD00866765
[MOL File]

15599-39-0.mol
[Molecular Weight]

120.17
Chemical PropertiesBack Directory
[Melting point ]

88-90°
[Boiling point ]

203.7±42.0 °C(Predicted)
[density ]

1.223±0.06 g/cm3(Predicted)
[pka]

13.45±0.10(Predicted)
Hazard InformationBack Directory
[Originator]

Noxyflex,Geistlich,UK,1964
[Definition]

ChEBI: Noxytiolin is a member of thioureas.
[Manufacturing Process]

400 g methyl thiourea and 2.5 g NaHCO3 are dissolved in 400 ml formaldehyde solution of 35% concentration. After having been left at ordinary temperature for 2 to 3 hours, the solution is adjusted with dilute HCl to pH 7 to 7.5. After the reaction mixture had been left overnight at 15°C some of the final product crystallized and was filtered off using a Buchner funnel. The mother liquor was concentrated by evaporation in vacuo at a bath-temperature of 30°C. The crystals obtained were again collected by filtration using a Buchner funnel and were combined with the first crystalline fraction and dried in vacuo at ordinary temperature. Yield of pure substance 400 g; melting point 84°C to 86°C.
[Therapeutic Function]

Antifungal
Safety DataBack Directory
[Toxicity]

LD50 orally in mice: >3 g/kg (Aebi, Hafstetter)
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