| Identification | Back Directory | [Name]
Embusartan | [CAS]
156001-18-2 | [Synonyms]
Embusartan
BAY 10-6734
UNII-4MY73645XA
6-n-Butyl-4-methoxycarbonyl-2-oxo-1-((2'-(1H-tetrazol-5-yl)-3-fluorobiphenyl-4-yl)methyl)-1,2-dihydropyridine
4-Pyridinecarboxylic acid, 6-butyl-1-[[3-fluoro-2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,2-dihydro-2-oxo-, methyl ester | [Molecular Formula]
C25H24FN5O3 | [MDL Number]
MFCD00930498 | [MOL File]
156001-18-2.mol | [Molecular Weight]
461.49 |
| Hazard Information | Back Directory | [Uses]
Embusartan (BAY 10-6734) is a brain-penetrant and effective AT1 receptor blocker. Embusartan inhibits Ang II binding to brain AT1 receptors in the nuclei of central nervous system (CNS) inside due to high lipophilic character. Embusartan is promising for research of sympathetic hyperactivity and hypertension[1]. | [References]
[1] Wang JM, et al. Central nervous system blockade by peripheral administration of AT1 receptor blockers. J Cardiovasc Pharmacol. 2003 Apr;41(4):593-9. DOI:10.1097/00005344-200304000-00012 |
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