| Identification | Back Directory | [Name]
Erinacine A
Erinacin A | [CAS]
156101-08-5 | [Synonyms]
(+)-Erinacin A
Erinacine A
Erinacin A
Cyclohept[e]indene-8-carboxaldehyde, 2,3,3a,4,5,5a,6,7-octahydro-3a,5a-dimethyl-1-(1-methylethyl)-6-(β-D-xylopyranosyloxy)-, (3aR,5aR,6S)- | [Molecular Formula]
C25H36O6 | [MOL File]
156101-08-5.mol | [Molecular Weight]
432.55 |
| Chemical Properties | Back Directory | [Boiling point ]
610.8±55.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
13.01±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
(+)-Erinacin A is a diterpenoid derivative isolated from the mushroom Hericium erinaceum. It can increase the catecholamine and nerve growth factor (NGF) content in the central nervous system of rats. | [in vivo]
(+)-Erinacin A (1, 5 and 10 mg/kg, i.p.; single dose) inhibits neuronal cell death in SAM rats with transient stroke and suppresses the expression of inflammatory cytokines in SAM brain tissues with transient stroke[4].
(+)-Erinacin A (1, 2 and 5 mg/kg, i.p.; once a day for 5 days) significantly reduces tumor volume in DLD-1 xenograft mice[5]. | Animal Model: | DLD-1 xenograft mouse model[5]. | | Dosage: | 1, 2 and 5 mg/kg | | Administration: | Intraperitoneal injection (i.p.) once a day for 5 days | | Result: | Inhibited tumor volume by 60%, 32% and 26%.
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| Animal Model: | SAM rats with transient stroke[4]. | | Dosage: | 1, 5 and 10 mg/kg | | Administration: | Intraperitoneal injection (i.p.) single dose | | Result: | Induced NeuN immune response in the entire brain region of SAM rats, and increased the number of NeuN cells.
Inhibited the activation of iNOS and p38/MAPK pathways and the expression of CHOP and nitrotyrosine proteins in rat brain tissue.
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
guoyungurui
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| Tel: |
18162595016; 18162595016 |
| Website: |
https://www.chemicalbook.com/supplier/25521782/ |
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