| Identification | Back Directory | [Name]
2-Propen-1-one, 1-(2-benzofuranyl)-3-(1-methyl-1H-indol-3-yl)- | [CAS]
1563260-97-8 | [Synonyms]
2-Propen-1-one, 1-(2-benzofuranyl)-3-(1-methyl-1H-indol-3-yl)- | [Molecular Formula]
C20H15NO2 | [MOL File]
1563260-97-8.mol | [Molecular Weight]
301.34 |
| Chemical Properties | Back Directory | [Boiling point ]
506.8±50.0 °C(predicted) | [density ]
1.18±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
TS-24 is an inhibitor for cathepsin S, with an IC50 of 4.3 μM. TS-24 exhibits radiosensitizing activity in wild type breast cancer susceptibility gene 1 (BRCA1) and in TNBC xenograft mice model, through induction of apoptosis[1]. | [in vivo]
TS-24 (1 mg/kg, i.p., 3 times a week for 6 weeks) inhibits tumor growth in TNBC xenograft mice model[1]. | Animal Model: | TNBC xenograft mice model>sup>[1] | | Dosage: | 1 mg/kg | | Administration: | i.p., 3 times a week for 6 weeks | | Result: | Inhibited tumor growth |
| [IC 50]
cathepsin S: 4.3 μM (IC50) | [References]
[1] Choi E, et al., Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple-negative breast cancer cells. Cancer Sci. 2024 Apr 13. DOI:10.1111/cas.16174 |
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