| Identification | Back Directory | [Name]
SX 3228 | [CAS]
156364-04-4 | [Synonyms]
SX 3228
1,6-Naphthyridin-2(1H)-one, 5,6,7,8-tetrahydro-3-(5-methoxy-1,3,4-oxadiazol-2-yl)-6-(phenylmethyl)- | [Molecular Formula]
C18H18N4O3 | [MDL Number]
MFCD00927851 | [MOL File]
156364-04-4.mol | [Molecular Weight]
338.36 |
| Hazard Information | Back Directory | [Uses]
SX-3228 is a selective benzodiazepine1 (BZ1) receptor agonist with an IC50 of 17 nM. | [in vivo]
Administration of 0.5-2.5 mg/kg SX-3228 to rats during the light phase induces a significant reduction of rapid-eye-movement sleep (REMS) (P<0.05) during the third recording hour. Administration of SX-3228 (0.5-2.5 mg/kg) at the beginning of the dark period significantly and dose-dependently reduces waking (W) and increases slow wave sleep (SWS) during the 6-h recording period (P<0.05-0.01); however, significant changes during the last recording hour are restricted to the 2.5 mg/kg dose (P<0.01)[1]. | [storage]
Store at -20°C | [References]
[1] Alvari?o F, et al. Effect of SX-3228, a selective ligand for the BZ1 receptor, on sleep and waking during the light-dark cycle in the rat. Braz J Med Biol Res. 1999 Aug;32(8):1007-14. DOI:10.1590/s0100-879x1999000800011 |
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