| Identification | Back Directory | [Name]
Pseudouridimycin (PUM) | [CAS]
1566586-52-4 | [Synonyms]
Pseudouridimycin
Pseudouridimycine
Pseudouridimycin (PUM)
2,4(1H,3H)-Pyrimidinedione, 5-[5-[[N-(aminoiminomethyl)glycyl-N2-hydroxy-L-glutaminyl]amino]-5-deoxy-β-D-ribofuranosyl]- | [Molecular Formula]
C17H26N8O9 | [MDL Number]
MFCD32215322 | [MOL File]
1566586-52-4.mol | [Molecular Weight]
486.44 |
| Chemical Properties | Back Directory | [density ]
1.91±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
7.75±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Pseudouridimycine is involved in the study of bacterial RNA polyemerase transcriptiion by trapping the open clamp state. Pseudouridimycin is an antibiotic from a new class of inhibitors that acts against Gram-positive and Gram-negative bacteria. | [in vivo]
Pseudouridimycin (3.2-50 mg/kg; iv; 10 min after infection and again 6 h after infection) clears infection in vivo in a mouse Streptococcus pyogenes peritonitis model (ED50 = 9 mg/kg)[3]. | Animal Model: | Female ICR mice (23-25 g) intraperitoneal injection of 0.5 mL saline solution (supplemented with 1% peptone) containing 4 × 103 cfu S. pyogenes C203[3]. | | Dosage: | 3.2 mg/kg, 8 mg/kg, 20 mg/kg, 50 mg/kg | | Administration: | iv; 10 min after infection and again 6 h after infection | | Result: | Showed antibacterial activity in vivo. |
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