| Identification | Back Directory | [Name]
harzianic acid | [CAS]
157148-06-6 | [Synonyms]
harzianic acid
2-Pyrrolidinepropanoic acid, α-hydroxy-4-[(2E,4E)-1-hydroxy-2,4-octadien-1-ylidene]-1-methyl-α-(1-methylethyl)-3,5-dioxo-, (αS,2S,4Z)- | [Molecular Formula]
C19H27NO6 | [MDL Number]
MFCD01759365 | [MOL File]
157148-06-6.mol | [Molecular Weight]
365.42 |
| Chemical Properties | Back Directory | [Melting point ]
85-86 °C(Solv: ethyl acetate (141-78-6)) | [Boiling point ]
619.6±55.0 °C(Predicted) | [density ]
1.225±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
3.75±0.32(Predicted) |
| Hazard Information | Back Directory | [Description]
Harzianic acid is a Trichoderma secondary metabolite.
Harzianic acid shows plant growth promotion activity.
3. Harzianic acid has antifungal activity and antibiotic activity against Pythium irregulare, Sclerotinia sclerotiorum, and Rhizoctonia solani. | [Uses]
Harzianic acid, a tetramic acid derivative, with activity of antimicrobial, antibiofilm formation and biofilm disaggregation. Harzianic acid interferes with biofilm formation by limiting bacterial iron availability. Harzianic acid is also a selective inhibitor of Acetohydroxyacid synthase (AHAS), the first enzyme in the branched-chain amino acid biosynthetic pathway. Harzianic acid can used for herbicide and fungicide[1][2]. | [target]
Antifection | [References]
[1] De Filippis A, et al. Antimicrobial activity of harzianic acid against Staphylococcus pseudintermedius. Nat Prod Res. 2021 Dec;35(23):5440-5445. DOI:10.1080/14786419.2020.1779714
[2] Xie L, et al. Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase. J Am Chem Soc. 2021 Jun 16:10.1021/jacs.1c03988. DOI:10.1021/jacs.1c03988. doi: 10.1021/jacs.1c03988 |
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