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157380-72-8

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157380-72-8 Structure

157380-72-8 Structure
IdentificationBack Directory
[Name]

TAK 044
[CAS]

157380-72-8
[Synonyms]

TAK 044
[Molecular Formula]

C45H51N9O11S.2Na
[MDL Number]

MFCD00927967
[MOL File]

157380-72-8.mol
[Molecular Weight]

971.996
Chemical PropertiesBack Directory
[Sequence]

cyclo({d-Asp}-{α-amino-γ-oxo-4-phenyl-1-piperazinebutanoyl-Asp}-Asp-{d-(2-thienyl)glycine}-Leu-{d-Trp}) (disodium salt)
Hazard InformationBack Directory
[Description]

TAK-044 is an Endothelin receptor antagonist. TAK-044 arrests and reverses the development of carbon tetrachloride induced cirrhosis in rats. TAK-044 showed protective effect on neuronal cell viability in in vitro oxygen-glucose deprivation model of stroke.
[Uses]

TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage[1].
[References]

[1] Toshifumi Watanabe, et al. TAK-044: An Endothelin Receptor Antagonist. , 14(1), 36–46.
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