| Identification | Back Directory | [Name]
2H-Pyrrol-2-one, 3-(4-cyclopropylphenoxy)-1,5-dihydro-1-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]- | [CAS]
1574538-43-4 | [Synonyms]
2H-Pyrrol-2-one, 3-(4-cyclopropylphenoxy)-1,5-dihydro-1-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]- | [Molecular Formula]
C26H30N2O4 | [MOL File]
1574538-43-4.mol | [Molecular Weight]
434.53 |
| Chemical Properties | Back Directory | [Boiling point ]
600.2±55.0 °C(predicted) | [density ]
1.243±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
9.53±0.20(predicted) |
| Hazard Information | Back Directory | [Uses]
MCHR1 antagonist 4 (Compound 2m) is a blood-brain barrier permeable MCHR1 antagonist with Ki values of 0.74 nM and 0.76 nM for hMCHR1 and rMCHR1, respectively. MCHR1 antagonist 4 is also an effective anti-obesity agent[1]. | [References]
[1] Yoon D S, et al. Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin-3 Comprising 2-Methyl-4-phenyl-2, 4-dihydro-3 H-1, 2, 4-triazole-3-thione[J]. Journal of Medicinal Chemistry, 2024. DOI:10.1021/acs.jmedchem.4c01008 |
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