| Identification | Back Directory | [Name]
2-Azabicyclo[3.3.1]nonan-7-one, 5-(3-hydroxyphenyl)-2-methyl-8-(phenylmethylene)-, (1R,5R,8E)- | [CAS]
157752-20-0 | [Synonyms]
2-Azabicyclo[3.3.1]nonan-7-one, 5-(3-hydroxyphenyl)-2-methyl-8-(phenylmethylene)-, (1R,5R,8E)- | [Molecular Formula]
C22H23NO2 | [MOL File]
157752-20-0.mol | [Molecular Weight]
333.42 |
| Hazard Information | Back Directory | [Description]
CB-64D is a sigma2R selective agonist which releases calcium in human neuroblastoma cells and produces cell death in tumor cell lines. | [Uses]
CB-64D is the agonist for sigma receptor 2 and sigma receptor 1 with Ki of 16.5 and 3063 nM. CB-64D induces apoptosis in cancer cell SK-N-SH[1][2]. | [IC 50]
Sigma 2 Receptor: 16.5 nM (Ki); Sigma 1 Receptor: 3063 nM (Ki) | [References]
[1] Nicholson H, et al., Characterization of CM572, a Selective Irreversible Partial Agonist of the Sigma-2 Receptor with Antitumor Activity. J Pharmacol Exp Ther. 2015 Aug;354(2):203-12. DOI:10.1124/jpet.115.224105
[2] Bowen WD, et al., CB-64D and CB-184: ligands with high sigma 2 receptor affinity and subtype selectivity. Eur J Pharmacol. 1995 May 24;278(3):257-60. DOI:10.1016/0014-2999(95)00176-l |
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