| Identification | Back Directory | [Name]
4-Quinazolinamine, 2-(3-pyridinyl)-N-(2-thienylmethyl)- | [CAS]
157862-84-5 | [Synonyms]
PDE5-IN-9
WAY-639921
4-Quinazolinamine, 2-(3-pyridinyl)-N-(2-thienylmethyl)-
2-(Pyridin-3-yl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine | [Molecular Formula]
C18H14N4S | [MOL File]
157862-84-5.mol | [Molecular Weight]
318.4 |
| Chemical Properties | Back Directory | [Boiling point ]
447.8±45.0 °C(Predicted) | [density ]
1.337±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
4.68±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PDE5-IN-9 (Compound 59) is a PDE5 inhibitor (IC50: 11.2 μM). PDE5-IN-9 shows interaction with Gln 817, Tyr 612, and Ala 767 amino acid residues. PDE5-IN-9 can be used for research of cardiovascular disease[1]. | [IC 50]
PDE5 | [References]
[1] Sarvesh Paliwal, et al. Pharmacophore and molecular docking based identification of novel structurally diverse PDE-5 inhibitors. Medicinal Chemistry Research. 2015, 24, 576-587. |
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