| Identification | Back Directory | [Name]
Benzamide, 5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]- | [CAS]
1580-42-3 | [Synonyms]
SARS-CoV-2-IN-15
Benzamide, 5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]- | [Molecular Formula]
C14H9ClF3NO2 | [MOL File]
1580-42-3.mol | [Molecular Weight]
315.67 |
| Chemical Properties | Back Directory | [Melting point ]
193-194 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
338.2±42.0 °C(Predicted) | [density ]
1.487±0.06 g/cm3(Predicted) | [pka]
7.67±0.43(Predicted) |
| Hazard Information | Back Directory | [Uses]
SARS-CoV-2-IN-15 (compound 11) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.49 μM. SARS-CoV-2-IN-15 is a niclosamide analogue. SARS-CoV-2-IN-15 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1]. | [References]
[1] Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295. DOI:10.1016/j.ejmech.2022.114295 |
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