| Identification | Back Directory | [Name]
Win 58237 | [CAS]
158001-76-4 | [Synonyms]
Win 58237
4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1-cyclopentyl-1,5-dihydro-3-methyl-6-(4-pyridinyl)- | [Molecular Formula]
C16H17N5O | [MDL Number]
MFCD00935798 | [MOL File]
158001-76-4.mol | [Molecular Weight]
295.34 |
| Hazard Information | Back Directory | [Uses]
Win 58237 is a cyclic nucleotide phosphodiesterase (PDE) inhibitor, with Ki of 170 nM for PDE V, possessing vasorelaxant activity. | [in vivo]
Win 58237 (0.3-3.0 mg/kg i.v.) decreases mean arterial pressure in conscious spontaneously hypertensive rats with an associated increase in vascular (aortic) cGMP content in vivo. Win 58237 (10 mg/kg i.v.) increases plasma cGMP levels, from basal levels of 6.7 ± 1.0 to 31.4 ± 3.5 fmol/μL[1]. | [storage]
Store at -20°C | [References]
[1] Silver PJ, et al. Cyclic GMP potentiation by WIN 58237, a novel cyclic nucleotide phosphodiesterase inhibitor. J Pharmacol Exp Ther. 1994 Dec;271(3):1143-9. PMID:7996419 |
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