| Identification | Back Directory | [Name]
S-2474 | [CAS]
158089-95-3 | [Synonyms]
S-2474
2,6-ditert-butyl-4-[(2-ethyl-1,1-dioxo-1,2-thiazolidin-5-ylidene)methyl]phenol
Phenol, 2,6-bis(1,1-dimethylethyl)-4-[(E)-(2-ethyl-1,1-dioxido-5-isothiazolidinylidene)methyl]- | [Molecular Formula]
C20H31NO3S | [MDL Number]
MFCD00929058 | [MOL File]
158089-95-3.mol | [Molecular Weight]
365.53 |
| Chemical Properties | Back Directory | [Melting point ]
135-137 °C | [Boiling point ]
462.7±55.0 °C(Predicted) | [density ]
1.129±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
11.28±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC50s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory agent. | [IC 50]
COX-2: 11 nM (IC50); COX-1: 27 μM (IC50); 5-LO | [storage]
Store at -20°C | [References]
[1] Yagami T, et al. Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid beta protein-induced neuronal cell death. Br J Pharmacol. 2001 Oct;134(3):673-81. DOI:10.1038/sj.bjp.0704261
[2] Yagami T, et al. S-2474, a novel nonsteroidal anti-inflammatory drug, rescues cortical neurons from human group IIA secretory phospholipase A(2)-induced apoptosis. Neuropharmacology. 2005 Aug;49(2):174-84. Epub 2005 Apr 1. DOI:10.1016/j.neuropharm.2005.02.011 |
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cjbscvictory
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13348960310 13348960310; |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
MedChemExpress
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021-58955995 |
| Website: |
www.medchemexpress.com |
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