| Identification | Back Directory | [Name]
1-Piperidinepropanenitrile, 3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-α-(2,2-dimethylpropylidene)-β-oxo-, (αE,3R)- | [CAS]
1581714-49-9 | [Synonyms]
SAR 444727
Atuzabrutinib
1-Piperidinepropanenitrile, 3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-α-(2,2-dimethylpropylidene)-β-oxo-, (αE,3R)- | [Molecular Formula]
C30H30FN7O2 | [MOL File]
1581714-49-9.mol | [Molecular Weight]
539.62 |
| Chemical Properties | Back Directory | [Boiling point ]
764.0±60.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
3.87±0.30(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Atuzabrutinib (SAR 444727) is a potent, selective reversible inhibitor of Btk (Bruton's tyrosine kinase) inhibitor. Atuzabrutinib inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling[1]. | [in vivo]
PRN473 (20 mg/kg) significantly reduces intravascular crawling and neutrophil recruitment into inflamed tissue in a model of sterile liver injury, down to levels seen in Btk-deficient animals[1]. | [References]
[1] Herter JM, et al. PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling. Br J Pharmacol. 2018;175(3):429-439. DOI:10.1111/bph.14090 |
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| Company Name: |
Wuhan Topule
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| Telephone: |
+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
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