| Identification | Back Directory | [Name]
ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE | [CAS]
15854-08-7 | [Synonyms]
AURORA 20241
AKOS MSC-0440
AKOS BBS-00000796
BUTTPARK 82\18-60
MFCD01827729,MFCD-01827729
Ethyl 2-amino-4-p-tolythiophene-3-carboxylate
ethyl 2-aMino-4-p-tolylthiophene-3-carboxylate
Ethyl 2-aMino-4-(p-tolyl)thiophene-3-carboxylate, 97+%
2-Amino-3-(ethoxycarbonyl)-4-(4-methylphenyl)thiophene
ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE
ETHYL 2-AMINO-4-(4-METHYLPHENYL)THIOPHENE-3-CARBOXYLATE
2-AMINO-4-P-TOLYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
2-amino-4-(4-methylphenyl)-3-thiophenecarboxylic acid ethyl ester
2-amino-4-(4-methylphenyl)thiophene-3-carboxylic acid ethyl ester
3-THIOPHENECARBOXYLIC ACID, 2-AMINO-4-(4-METHYLPHENYL)-, ETHYL ESTER | [Molecular Formula]
C14H15NO2S | [MDL Number]
MFCD01827729 | [MOL File]
15854-08-7.mol | [Molecular Weight]
261.34 |
| Chemical Properties | Back Directory | [Melting point ]
105-107℃ | [Boiling point ]
401.5±45.0 °C(Predicted) | [density ]
1.203±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [form ]
solid | [pka]
-0.04±0.14(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
aPKC-IN-2 is a small molecule inhibitor that inhibits aPKC activity. aPKC-IN-2 can effectively block vascular endothelial permeability in cell culture and in vivo experiments. aPKC-IN-2 shows biological activity in interfering with NFκB-driven gene transcription and is associated with inflammatory responses. aPKC-IN-2 has a significant inhibitory effect on vascular endothelial permeability induced by VEGF and TNF, and its EC50 value is in the low nanomolar range. The structural characteristics of aPKC-IN-2 reveal key elements of its inhibitory activity, providing the possibility for further development of small molecule aPKC inhibitors[1]. | [References]
[1] Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors |
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| Company Name: |
Alfa Aesar
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| Tel: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
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