Identification | Back Directory | [Name]
nitroflurbiprofen | [CAS]
158836-71-6 | [Synonyms]
HCT 1206 nitroflurbiprofen Nitroxybutyl flurbiprofen [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-α-methyl-, 4-(nitrooxy)butyl ester | [Molecular Formula]
C19H20FNO5 | [MDL Number]
MFCD00871245 | [MOL File]
158836-71-6.mol | [Molecular Weight]
361.36 |
Chemical Properties | Back Directory | [Boiling point ]
468.8±45.0 °C(Predicted) | [density ]
1.214±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Oil | [color ]
Colorless to light yellow |
Hazard Information | Back Directory | [Uses]
Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats. | [Definition]
ChEBI: A carboxylic ester obtained by formal condensation of the carboxy group of flurbiprofen with the free hydroxy group of 4-(nitrooxy)butanol. It is a non-steroidal anti-inflammatory agent showing inhibitory effects against the cyclooxygenases COX1 and COX2. | [in vivo]
In vivo hemodynamic measurements (n = 8/condition) and evaluation of the increased intrahepatic resistance by in situ perfusion (n=5/condition) are performed in rats with thioacetamide-induced cirrhosis that receive either Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle by intraperitoneal injection 24 hours and 1 hour prior to the measurements. Treatment with Nitroflurbiprofen, an NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors[1]. | [IC 50]
COX | [storage]
Store at -20°C | [References]
[1] Laleman W, et al. Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portalhypertension in rats. Gastroenterology. 2007 Feb;132(2):709-19. DOI:10.1053/j.gastro.2006.12.041 |
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