| Identification | Back Directory | [Name]
5-(methoxymethyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE) | [CAS]
15884-86-3 | [Synonyms]
5-(methoxymethyl)-1,3,4-thiadiazol-2-amine(SALTDATA: FREE)
1,3,4-Thiadiazol-2-amine, 5-(methoxymethyl)- CAS NO:15884-86-3 | [Molecular Formula]
C4H7N3OS | [MDL Number]
MFCD01203002 | [MOL File]
15884-86-3.mol | [Molecular Weight]
145.18 |
| Chemical Properties | Back Directory | [Boiling point ]
279.1±42.0 °C(Predicted) | [density ]
1.359±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
solid | [pka]
2.90±0.10(Predicted) | [color ]
Light yellow |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine a25: Aminothiourea a24 (40 g, 0.44 mol, 1 eq.) was suspended in dioxane (400 mL) at room temperature, followed by a one-time addition of methoxyacetic acid (39.56 g, 0.44 mol, 1 eq.). The reaction mixture was heated to 80 °C and phosphorus trichloride (67.54 g, 0.44 mol, 1 eq.) was added slowly and dropwise over 1.5 hours. After completion of the reaction (4 h), water was added and the solution was neutralized to pH 6-7 using sodium hydroxide pellets. after extraction with EtOAc/iPrOH (9/1) mixed solvent, the solvent was evaporated in vacuum and the residue was recrystallized by MeTHF/iPrOH mixed solvent to afford pure 5-(methoxymethyl)-1,3,4-thiadiazol-2-amine a25 (51 g, yield 81%).LC-MS (MH+): 146. | [References]
[1] Patent: WO2011/47860, 2011, A1. Location in patent: Page/Page column 25
[2] Patent: US4090026, 1978, A |
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