| Identification | Back Directory | [Name]
Tankyrase-IN-2 | [CAS]
1588870-36-3 | [Synonyms]
Tankyrase-IN-2
TankyraseIN2,Tankyrase IN 2
4(3H)-Quinazolinone, 6,8-difluoro-2-[4-(1-hydroxy-1-methylethyl)phenyl]- | [Molecular Formula]
C17H14F2N2O2 | [MDL Number]
MFCD32197230 | [MOL File]
1588870-36-3.mol | [Molecular Weight]
316.3 |
| Chemical Properties | Back Directory | [Boiling point ]
466.3±55.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 10mg/mL; DMSO: 10mg/mL; Ethanol: 10mg/mL; Ethanol:PBS (pH 7.2) (1:30): 0.025mg/mL | [form ]
A crystalline solid | [pka]
13.89±0.29(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Tankyrase-IN-2 (compound 5k) is a potent, selective, and orally active tankyrase inhibitor (IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively). Tankyrase-IN-2 has favorable physicochemical profile and pharmacokinetic properties modulating Wnt pathway activity in a colorectal xenograft model[1]. | [References]
[1] Buchstaller HP, et al. Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective TankyraseInhibitor Modulating Wnt Pathway Activity. J Med Chem. 2019 Aug 5. DOI:10.1021/acs.jmedchem.9b00656 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
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