| Identification | Back Directory | [Name]
SC57666 | [CAS]
158959-32-1 | [Synonyms]
SC57666
Benzene, 1-fluoro-4-[2-[4-(methylsulfonyl)phenyl]-1-cyclopenten-1-yl]- | [Molecular Formula]
C18H17FO2S | [MDL Number]
MFCD00930301 | [MOL File]
158959-32-1.mol | [Molecular Weight]
316.39 |
| Chemical Properties | Back Directory | [Melting point ]
146-147 °C | [Boiling point ]
472.1±45.0 °C(Predicted) | [density ]
1.253±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: ≥ 100 mg/mL (316.07 mM) | [form ]
Solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
SC57666 is a selective COX2 inhibitor with an IC50 of 26 nM. | [Definition]
ChEBI: SC-57666 is a stilbenoid. | [in vivo]
SC57666 has been shown to be orally active (ED50=1.7 mpk) in the adjuvant-induced arthritis model. No gastric lesions are observed in mice after 5 h when SC57666 is administered intragastrically at 600 mpk. No intestinal damage is observed in rats after 72 h when SC57666 is administered intragastrically at 200 mpk[1]. | [IC 50]
COX-2: 26 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Reitz DB, et al. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally activeCOX2 inhibitors. J Med Chem. 1994 Nov 11;37(23):3878-81. DOI:10.1021/jm00049a005
[2] Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. DOI:10.1038/sj.bjp.0701076 |
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