| Identification | Back Directory | [Name]
1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE | [CAS]
158985-25-2 | [Synonyms]
1-Boc-4-(4-Hydroxy-P
4-(4-Boc-1-piperazinyl)phenol
N-Boc-4-(4-hydroxyphenyl)piperazine
1-BOC-4-(4-HYDROXY-PHENYL)-PIPERAZINE
4-(4-Hydroxyphenyl)piperazine, N1-Boc protected
tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate
4-(4-hydroxyphenyl)-1-piperazinecarboxylic acid tert-butyl ester
4-(4-HYDROXY-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
1-(4-HYDROXY-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
1-Piperazinecarboxylic acid, 4-(4-hydroxyphenyl)-, 1,1-dimethylethyl ester | [Molecular Formula]
C15H22N2O3 | [MDL Number]
MFCD04115060 | [MOL File]
158985-25-2.mol | [Molecular Weight]
278.35 |
| Chemical Properties | Back Directory | [Boiling point ]
436.0±40.0 °C(Predicted) | [density ]
1.167±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [pka]
12.18±0.30(Predicted) | [Appearance]
Light brown to brown Solid | [InChI]
InChI=1S/C15H22N2O3/c1-15(2,3)20-14(19)17-10-8-16(9-11-17)12-4-6-13(18)7-5-12/h4-7,18H,8-11H2,1-3H3 | [InChIKey]
YEHWSWXESXPBOS-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(O)C=C2)CC1 |
| Hazard Information | Back Directory | [Synthesis]
To a solution of 4-(1-piperazinyl)phenol (2.0 g, 11.22 mmol) in water (56 mL) was added sodium hydroxide (673 mg, 16.83 mmol) followed by di-tert-butyl dicarbonate (2.7 g, 12.34 mmol). The reaction mixture was stirred at room temperature overnight. On the next day, the reaction mixture was filtered and tert-butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate was collected as a brown solid (3.1 g, 99% yield), which was washed with water (50 mL) and used for the next reaction without further purification.1H NMR (300 MHz, DMSO-d6): δ 6.79 (AA'BB', 2H, JAB = 9.1 Hz. JAA' = 2.4 Hz), 6.66 (AA'BB', 2H, JAB = 9.1 Hz, JBB' = 2.4 Hz), 3.43 (dd, 4H, J = 5.3,4.9 Hz), 2.88 (dd, 4H, J = 5.2,5.1 Hz), 1.41 (s, 9H); 13C NMR (75.5 MHz, DMSO-d6 ): δ153.8,151.4,144.0,118.5,115.4,78.8,50.3,28.0. | [References]
[1] Patent: WO2008/83056, 2008, A2. Location in patent: Page/Page column 51
[2] European Journal of Organic Chemistry, 2009, # 25, p. 4290 - 4299
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 5, p. 1035 - 1049
[4] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 2, p. 215 - 220
[5] Patent: WO2017/93491, 2017, A1. Location in patent: Page/Page column 3; 12 |
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