| Identification | Back Directory | [Name]
Androst-4-en-3-one, 16,17-[(1R)-butylidenebis(oxy)]-6,9-difluoro-11-hydroxy-17-(methylthio)-, (6α,11β,16α,17β)- | [CAS]
159001-35-1 | [Synonyms]
Androst-4-en-3-one, 16,17-[(1R)-butylidenebis(oxy)]-6,9-difluoro-11-hydroxy-17-(methylthio)-, (6α,11β,16α,17β)- | [Molecular Formula]
C24H34F2O4S | [MOL File]
159001-35-1.mol | [Molecular Weight]
456.59 |
| Hazard Information | Back Directory | [Uses]
RPR-106541 is a 17-thiosteroid. RPR 106541 has potent glucocorticosteroid activity. RPR 106541 also has demonstrable effects on carbohydrate and lipid metabolism[1]. | [in vivo]
RPR-106541 significantly inhibits CD4+ T-cell accumulation and eosinophil accumulation within the lungs and simultaneously inhibits expression of mRNA for interleukin (IL)-4 and IL-5 in an experimental rat model of pulmonary inflammation[1]. | [IC 50]
IL-4; IL-5 | [References]
[1] Miller GK, et al. Chronic effects of the novel glucocorticosteroid RPR 106541 administered to beagle dogs by inhalation. Toxicol Pathol. 2000 Mar-Apr;28(2):226-36. DOI:10.1177/019262330002800202 |
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