| Identification | Back Directory | [Name]
TERT-BUTYL N-(4-IODOPHENYL)CARBAMATE | [CAS]
159217-89-7 | [Synonyms]
N-BOC-4-IODOANILINE
TERT-BUTYL 4-IODOPHENYLCARBAMATE
TERT-BUTYL N-(4-IODOPHENYL)CARBAMATE
N-(tert-Butoxycarbonyl)-4-iodoaniline
(4-Iodophenyl)carbamic acid tert-butyl ester
N-(4-iodophenyl)carbamic acid tert-butyl ester
Carbamic acid, N-(4-iodophenyl)-, 1,1-dimethylethyl ester | [Molecular Formula]
C11H14INO2 | [MDL Number]
MFCD03490497 | [MOL File]
159217-89-7.mol | [Molecular Weight]
319.14 |
| Chemical Properties | Back Directory | [Melting point ]
146-147°C | [Boiling point ]
299.0±23.0 °C(Predicted) | [density ]
1.591±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
solid | [pka]
13.12±0.70(Predicted) | [Appearance]
White to off-white Solid | [Sensitive ]
Light Sensitive | [InChI]
1S/C11H14INO2/c1-11(2,3)15-10(14)13-9-6-4-8(12)5-7-9/h4-7H,1-3H3,(H,13,14) | [InChIKey]
CGALRQWBJFDAKN-UHFFFAOYSA-N | [SMILES]
CC(C)(C)OC(=O)Nc1ccc(I)cc1 |
| Hazard Information | Back Directory | [Synthesis]
GENERAL STEPS: The reaction was carried out in a 50 mL round-bottomed flask at 80°C under reduced pressure for 10 minutes. In a typical experiment, 5 mmol of p-iodoaniline was mixed with 5 mmol of di-tert-butyl dicarbonate and the reaction lasted for 10 minutes. Upon completion of the reaction, the solvent was removed by rotary evaporator under vacuum to give tert-butyl (4-iodophenyl)carbamate. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 22, p. 5864 - 5869
[2] Research on Chemical Intermediates, 2017, vol. 43, # 3, p. 1355 - 1363
[3] Chemical Communications, 2013, vol. 49, # 61, p. 6909 - 6911
[4] Patent: WO2004/12736, 2004, A1. Location in patent: Page/Page column 24
[5] Organic Letters, 2018, vol. 20, # 7, p. 1693 - 1697 |
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