| Identification | Back Directory | [Name]
(R)-CE3F4
(CE3F4 (R)-enantiomer) | [CAS]
1593478-56-8 | [Synonyms]
(R)-CE3F4
(R)-CE-3F4,(R) CE3F4,(R)CE3F4
(R)-CE3F4
(CE3F4 (R)-enantiomer)
(2R)-5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
1(2H)-Quinolinecarboxaldehyde, 5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-, (2R)- | [Molecular Formula]
C11H10Br2FNO | [MDL Number]
MFCD31579856 | [MOL File]
1593478-56-8.mol | [Molecular Weight]
351.01 |
| Chemical Properties | Back Directory | [Boiling point ]
431.1±45.0 °C(Predicted) | [density ]
1.842±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
-1.07±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
(R)-CE3F4 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM). (R)-CE3F4 is more potent than racemic CE3F4 and (S)-CE3F4[1]. | [storage]
Store at -20°C | [References]
[1] Courilleau D, et al. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem Biophys Res Commun. 2013 Oct 25;440(3):443-8. DOI:10.1016/j.bbrc.2013.09.107 |
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