| Hazard Information | Back Directory | [Description]
WB403 is a TGR5 activator. WB403 significantly improves glucose tolerance and decreases fasting blood glucose, postprandial blood glucose and HbA1c in type 2 diabetic mice. WB403 also increases pancreatic β-cells and restores the normal distribution pattern of α-cell and β-cell in islets. | [Uses]
WB403 is a TGR5 activator. WB403 promotes GLP-1 release, improved hyperglycemia, and preserves the mass and function of pancreatic β-cells[1]. | [References]
[1] Zheng C, et al. A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-Cells in Type 2 Diabetic Mice. PLoS One. 2015 Jul 24;10(7):e0134051. DOI:10.1371/journal.pone.0134051 |
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