| Identification | Back Directory | [Name]
4-(1-(benzo[d][1,3]dioxol-5-yl)-2-(4-isopropylphenylsulfonamido)-2-oxoethoxy)-3-propylbenzoic acid(WXG01788) | [CAS]
159590-37-1 | [Synonyms]
L749329
L-749329
L 749329
4-(1-(benzo[d][1,3]dioxol-5-yl)-2-(4-isopropylphenylsulfonamido)-2-oxoethoxy)-3-propylbenzoic acid
4-(1-(benzo[d][1,3]dioxol-5-yl)-2-(4-isopropylphenylsulfonamido)-2-oxoethoxy)-3-propylbenzoic acid(WXG01788) | [Molecular Formula]
C28H29NO8S | [MOL File]
159590-37-1.mol | [Molecular Weight]
539.6 |
| Hazard Information | Back Directory | [Description]
L-749329 is a dual ET(A)/ET(B) endothelin receptor ligand. | [Uses]
L-749329 ((Rac)-L-754142) is an ETA and ETB receptor antagonist, with Kis of 0.062 nM and 2.25 nM for ETA and ETB respectively. L-749329 inhibits ET-1-stimulated signaling[1]. | [References]
[1] Huckle WR, et al. Effects of L-749,329, an ET(A)/ET(B) endothelin receptor antagonist, in a porcine coronary artery injury model of vascular restenosis. Circulation. 2001 Apr 10;103(14):1899-905. DOI:10.1161/01.cir.103.14.1899 |
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