| Identification | Back Directory | [Name]
JPH203 HCl | [CAS]
1597402-27-1 | [Synonyms]
JPH203 HCl
JPH203 HCI
nanvuranlat
JPH203 2HCl
JPH203 Dihydrochloride
KYT-0353 dihydrochloride
JPH-203 dihydrochloride,JPH203 dihydrochloride
JPH203 DIHYDROCHLORIDE; JPH203 HCL; JPH203; JPH-203; JPH 203; KYT-0353; KYT 0353; KYT0353. | [Molecular Formula]
C23H20Cl3N3O4 | [MOL File]
1597402-27-1.mol | [Molecular Weight]
508.78 |
| Hazard Information | Back Directory | [Description]
JPH203 is an inhibitor of L-type amino acid transporter 1 (LAT1; IC50 = 0.14 μM for 14C-leucine uptake in S2 cells expressing the human transporter).1 It is selective for LAT1 over LAT2 (IC50 = >10 μM). JPH203 inhibits 14C-leucine uptake by, and growth of, HT-29 cells (IC50s = 0.06 and 4.1 μM, respectively). It induces apoptosis and increases levels of cleaved caspase-3, caspase-7, caspase-9, and poly(ADP-ribose) polymerase (PARP) in YD-38 oral cancer cells when used at a concentration of 3 mM.2 JPH203 (6.3, 12.5, and 25 mg/kg) reduces tumor growth in an HT-29 mouse xenograft model.1WARNING This product is not for human or veterinary use. | [storage]
Store at -20°C |
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