| Identification | Back Directory | [Name]
ML401 | [CAS]
1597489-14-9 | [Synonyms]
ML401
CID73169083
ML401 (CID73169083)
ML401,Inhibitor,ML 401,EBI2/GPR183,inhibit,ML-401
(E)-3-(4-Bromophenyl)-1-(4-(4-chlorobenzyl)piperazin-1-yl)prop-2-en-1-one
2-Propen-1-one, 3-(4-bromophenyl)-1-[4-[(4-chlorophenyl)methyl]-1-piperazinyl]-, (2E)- | [Molecular Formula]
C20H20BrClN2O | [MOL File]
1597489-14-9.mol | [Molecular Weight]
419.74 |
| Chemical Properties | Back Directory | [Boiling point ]
557.2±50.0 °C(Predicted) | [density ]
1.422±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 10.42 mg/mL (24.82 mM) | [form ]
Solid | [pka]
5.99±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity[1]. | [in vivo]
ML401 shows very good stability in both human plasma and mouse plasma[1]. | [storage]
Store at -20°C | [References]
[1] Ardecky R, et al. Functional Antagonists of EBI-2. Probe Reports from the NIH Molecular Libraries Program [Internet]. PMID:25834900 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
|