| Identification | Back Directory | [Name]
(S)-methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)propanoate | [CAS]
1598424-76-0 | [Synonyms]
spudl 05650
BMS466442,BMS 466442
L-Histidine, N-[[5-methoxy-6-(phenylmethoxy)-1H-indol-2-yl]carbonyl]-1-(phenylmethyl)-, methyl ester
(S)-methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-(benzyloxy)-5-methoxy-1H-indole-2-carboxamido)propanoate | [Molecular Formula]
C31H30N4O5 | [MOL File]
1598424-76-0.mol | [Molecular Weight]
538.59 |
| Chemical Properties | Back Directory | [Boiling point ]
827.3±65.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
-10 to -25°C | [solubility ]
Soluble to 100 mM in DMSO | [form ]
Solid | [pka]
13.15±0.46(Predicted) | [color ]
Off-white to yellow |
| Hazard Information | Back Directory | [Uses]
BMS-466442 is a potent and selective inhibitor of asc-1 (alanine serine cysteine transporter-1), with an IC50 of 11 nM. BMS-466442 inhibits [3H] D-serine uptake into rat brain synaptosomes, with an IC50 of 400 nM. BMS-466442 can be used for schizophrenia research[1][2]. | [Biological Activity]
Potent and selective alanine serine cysteine transporter-1 (ASC-1; SLC7A10) inhibitor th at effectively blocks ASC-1-mediated cellular D-Ser uptake.
BMS-466442 is a selective alanine serine cysteine transporter-1 (ASC-1) inhibitor (D-Ser uptake IC50 = 36.8 nM and 19.7 nM using HEK human ASC-1 transfectants or primary r at embryonic cortical culturesrespectively) with good selectivity over >40 other targetsincluding LAT-2 or ASCT-2 (IC50 >10 μM). | [IC 50]
α adrenergic receptor: ≥10 μM (IC50); ASCT1: 1 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Brown JM, et al. In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10). J Neurochem. 2014 Apr;129(2):275-83. DOI:10.1111/jnc.12618
[2] Torrecillas IR, et al. Inhibition of the Alanine-Serine-Cysteine-1 Transporter by BMS-466442. ACS Chem Neurosci. 2019 May 15;10(5):2510-2517. DOI:10.1021/acschemneuro.9b00019 |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|