| Identification | Back Directory | [Name]
ADRENOMEDULLIN (22-52) (HUMAN) | [CAS]
159899-65-7 | [Synonyms]
TY-31-NH2
22-52-Human adrenomedullin
Human adrenomedullin(22-52)
22-52-Adrenomedullin (human)
ADRENOMEDULLIN (HUMAN, 22-52)
ADRENOMEDULLIN (22-52) (HUMAN)
Adrenomedullin (AM) (22-52), human
ADRENOMEDULLIN FRAGMENT 22-52 HUMAN
TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2
ADRENOMEDULLIN (22-52) (HUMAN) USP/EP/BP
51: PN: US20050009742 PAGE: 20 claimed sequence
Adrenomedullin Fragment 22-52 human >=97% (HPLC)
THR-VAL-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-ASN-VAL-ALA-PRO-ARG-SER-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2
H-THR-VAL-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-ASN-VAL-ALA-PRO-ARG-SER-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2
THR-VAL-GLN-LYS-LEU-ALA-HIS-GLN-ILE-TYR-GLN-PHE-THR-ASP-LYS-ASP-LYS-ASP-ASN-VAL-ALA-PRO-ARG-SER-LYS-ILE-SER-PRO-GLN-GLY-TYR-NH2: TVQKLAHQIYQFTDKDKDNVAPRSKISPQGY-NH2
Adrenomedullin (22-52) (human) trifluoroacetate salt H-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2 trifluoroacetate salt
L-Tyrosinamide, L-threonyl-L-valyl-L-glutaminyl-L-lysyl-L-leucyl-L-alanyl-L-histidyl-L-glutaminyl-L-isoleucyl-L-tyrosyl-L-glutaminyl-L-phenylalanyl-L-threonyl-L-α-aspartyl-L-lysyl-L-α-aspartyl-L-lysyl-L-α-aspartyl-L-asparaginyl-L-valyl-L-alanyl-L-prolyl-L-arginyl-L-seryl-L-lysyl-L-isoleucyl-L-seryl-... | [Molecular Formula]
C159H252N46O48 | [MDL Number]
MFCD00282038 | [MOL File]
159899-65-7.mol | [Molecular Weight]
3575.98 |
| Chemical Properties | Back Directory | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [color ]
White to off-white | [Sequence]
H-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2 |
| Hazard Information | Back Directory | [Uses]
Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat[1][2]. | [Biochem/physiol Actions]
Adrenomedullin Fragment 22-52 [ADM22-52] is used as an adrenomedullin (ADM) receptor antagonist to study the functions and mechanism of action of ADM signaling. ADM(22-52) is used to differentiate adrenomedullin binding sites in various cells and tissues. | [References]
[1] Champion HC, et al. Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat. Am J Physiol. 1997 Jan;272(1 Pt 2):R234-42. DOI:10.1152/ajpregu.1997.272.1.R234
[2] Ziolkowska A, et al. Effects of adrenomedullin and its fragment 22-52 on basal and ACTH-stimulated secretion of cultured rat adrenocortical cells. Int J Mol Med. 2003 May;11(5):613-5. PMID:12684698 |
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