| Identification | Back Directory | [Name]
H-D-Phe-Pip-Arg-pNA hydrochloride | [CAS]
160192-34-7 | [Synonyms]
H-D-Phe-Pip-Arg-pNA hydrochloride | [Molecular Formula]
C27H37ClN8O5 | [MDL Number]
MFCD34470667 | [MOL File]
160192-34-7.mol | [Molecular Weight]
589.09 |
| Chemical Properties | Back Directory | [solubility ]
DMSO: soluble | [form ]
A solid | [color ]
Light yellow to yellow | [InChIKey]
YEOVJZRYPLLHJL-IAYLHCNXNA-N | [SMILES]
C([C@@H]1CCCCN1C(=O)[C@H](N)CC1C=CC=CC=1)(=O)N[C@@H](CCCNC(N)=N)C(=O)NC1C=CC(N(=O)=O)=CC=1.Cl |&1:1,9,20,r| |
| Hazard Information | Back Directory | [Uses]
H-D-Phe-Pip-Arg-pNA (S-2238) hydrochloride, a chromogenic substrate, is patterned after the N-terminal portion of the A alpha chain of fibrinogen, which is the natural substrate of thrombin. H-D-Phe-Pip-Arg-pNA hydrochloride is specific for thrombin and is used to measure antithrombin-heparin cofactor (AT-III). The AT-III assay using H-D-Phe-Pip-Arg-pNA hydrochloride is sensitive, accurate, and easy to perform[1][2]. | [References]
[1] Goodnight SH Jr, et al. Measurement of antithrombin III in normal and pathologic states using chromogenic substrate S-2238. Comparison with immunoelectrophoretic and factor Xa inhibition assays. Am J Clin Pathol. 1980;73(5):639-647. DOI:10.1093/ajcp/73.5.639
[2] van Voorthuizen H, Kluft C. Improved assay conditions for automated antithrombin III determinations with the chromogenic substrate S-2238. Thromb Haemost. 1984;52(3):350-353. PMID:6531759 |
|
|