| Identification | Back Directory | [Name]
Reaxys ID: 26778003 | [CAS]
1604034-78-7 | [Synonyms]
Reaxys ID: 26778003
11H-Indolo[3,2-c]quinoline-9-carbonitrile, 2-methoxy-3-[2-(2-methoxyethoxy)ethoxy]- | [Molecular Formula]
C22H21N3O4 | [MDL Number]
MFCD32173205 | [MOL File]
1604034-78-7.mol | [Molecular Weight]
391.42 |
| Hazard Information | Back Directory | [Uses]
IRAK4-IN-29 is an IRAK4 inhibitor with good selectivity and low nanomolar activity. IRAK4-IN-29 can effectively block the TLR-mediated signal transduction pathway. IRAK4-IN-29 showed significant inhibitory effects in LPS- and R848-induced cytokine experiments. IRAK4-IN-29 can inhibit LPS-induced TNFα in an in vivo model, showing a similar phenotype to IRAK4 gene-deficient mice. IRAK4-IN-29 has good medicinal chemical properties, such as microsomal stability and solubility, showing potential clinical application value[1]. | [References]
[1] Identification and optimization of indolo[2,3-c]quinoline inhibitors of IRAK4 |
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