| Identification | Back Directory | [Name]
bio-THZ1 | [CAS]
1604811-14-4 | [Synonyms]
BIO-THZ1
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[(2E)-1-[[4-[[[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]amino]carbonyl]phenyl]amino]-5-methyl-1,10-dioxo-14,17,20-trioxa-5,9,11-triazadocos-2-en-22-yl]hexahydro-2-oxo-, (3aS,4S,6aR)- | [Molecular Formula]
C52H65ClN12O8S | [MDL Number]
MFCD32201112 | [MOL File]
1604811-14-4.mol | [Molecular Weight]
1053.67 |
| Chemical Properties | Back Directory | [density ]
1.314±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 120 mg/mL (113.89 mM; Need ultrasonic) | [form ]
Solid | [pka]
12.87±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7. THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3.2 nM[1]. | [storage]
Store at -20°C | [References]
[1] Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20. DOI:10.1038/nature13393 |
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https://www.weikeqi-biotech.com/ |
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