| Identification | Back Directory | [Name]
compoundk | [CAS]
160729-91-9 | [Synonyms]
L-754,394
Aids096249
Aids-096249
N-(2(R)-Hydroxy-1(S)-indany)-2(R)-phenylmethyl-4(S)-hydroxy-5-(1-(4-(5-furo[2,3-B]pyridylmethyl)- 2(S)-N'-(tert-butylcarboxamido)piperazinyl)) pentanamide
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(furo[2,3-b]pyridin-5-ylmethyl)piperazine-2-carboxamide
D-erythro-Pentonamide, 2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(furo[2,3-b]pyridin-5-ylmethyl)-1-piperazinyl]-2-(phenylmethyl)- | [Molecular Formula]
C38H47N5O5 | [MDL Number]
MFCD00871603 | [MOL File]
160729-91-9.mol | [Molecular Weight]
653.81 |
| Chemical Properties | Back Directory | [Melting point ]
184-185 °C | [Boiling point ]
903.1±65.0 °C(Predicted) | [density ]
1.29±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [pka]
14.39±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
HIV-IN-11 is part of the hydroxylaminoglutaramide (HAPA) transition state isomeric series of HIV protease inhibitors and is a potent and selective inhibitor of HIV-1 protease. HIV-IN-11 competitively inhibits HIV-1 PR (Ki: 0.049 nM) and potently inhibits replication of HIV(IIIb)-infected MT4 lymphocytes at concentrations of 25.0-50.0 nM. HIV-IN-11 displays a longer half-life than indinavir sulfate in animal models and serves as a promising second-generation HIV protease inhibitor[1]. | [References]
[1] Dorsey BD, et al. Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors. J Med Chem. 2000 Sep 7;43(18):3386-99. DOI:10.1021/jm9903848 |
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LGM Pharma
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www.lgmpharma.com |
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Matrix Scientific
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803 788-9494 All other calls |
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www.matrixscientific.com |
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A.T.CHEMICAL
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