| Identification | Back Directory | [Name]
2,3-Dihydro-3alpha-methoxynimbolide | [CAS]
1607828-35-2 | [Synonyms]
2,3-Dihydro-3α-methoxynimbolide
2,3-Dihydro-3α-methoxynimbolide
2,3-Dihydro-3alpha-methoxynimbolide
2H,3H-Cyclopenta[d']naphtho[1,8-bc:2,3-b']difuran-6-acetic acid, 8-(3-furanyl)-2a,4,5,5a,6,6a,8,9,9a,10a,10b,10c-dodecahydro-3-methoxy-2a,5a,6a,7-tetramethyl-2,5-dioxo-, methyl ester, (2aS,3R,5aR,6S,6aR,8R,9aR,10aS,10bR,10cR)- | [Molecular Formula]
C28H34O8 | [MOL File]
1607828-35-2.mol | [Molecular Weight]
498.56 |
| Hazard Information | Back Directory | [Uses]
2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521[1]. | [References]
[1] Manosroi A, et al. Limonoids from Azadirachta indica var. siamensis extracts and their cytotoxic and melanogenesis-inhibitory activities. Chem Biodivers. 2014;11(4):505-531. DOI:10.1002/cbdv.201300406 |
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