| Hazard Information | Back Directory | [Description]
Sofpironium bromide is a topical anticholinergic drug administered in gel form (5%) for the treatment of primary axillary hyperhidrosis (PAH).
| [Uses]
Sofpironium bromide is used for the topical treatment of primary axillary hyperhidrosis that is not treatable with topical antiperspirants.
| [Mechanism of action]
Sofpironium bromide treats hyperhidrosis by inhibiting the M3 muscarinic receptors, thereby reducing the activity of sweat glands.
| [Synthesis]
Acid 106 and alcohol 109 were coupled using CDI (carbodiimide) as a coupling agent to form ester 110. Ester 110 was alkylated with ethyl methyl bromide to afford soperidinium bromide, which was isolated as a crystalline solid in several interconvertible crystalline forms.
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