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160790-21-6

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160790-21-6 Structure

160790-21-6 Structure
IdentificationBack Directory
[Name]

GP2
[CAS]

160790-21-6
[Synonyms]

GP2
IISAVVGIL
HER-2/NEU (654-662)
HER2/NEU (654-662) GP2
ILE-ILE-SER-ALA-VAL-VAL-GLY-ILE-LEU
H-ILE-ILE-SER-ALA-VAL-VAL-GLY-ILE-LEU-OH
[Molecular Formula]

C42H77N9O11
[MDL Number]

MFCD00950499
[MOL File]

160790-21-6.mol
[Molecular Weight]

884.11
Chemical PropertiesBack Directory
[Boiling point ]

1209.5±65.0 °C(Predicted)
[density ]

1.147±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

3.41±0.10(Predicted)
[color ]

White to off-white
[Sequence]

Ile-Ile-Ser-Ala-Val-Val-Gly-Ile-Leu
Hazard InformationBack Directory
[Uses]

HER2/neu (654-662) GP2 is a nine amino acid peptide derived from the human epidermal growth factor receptor 2 (HER2/nue, 654–662), induces HLA-A2-restricted cytotoxic T lymphocytes (CTL) reactive to various epithelial cancers[1][2].
[References]

[1] Sun Y, et al. Observing the temperature dependent transition of the GP2 peptide using terahertz spectroscopy. PLoS One. 2012;7(11):e50306. DOI:10.1371/journal.pone.0050306
[2] Tanaka Y, et al. Modification of the HER2/NEU-derived tumor antigen GP2 improves induction of GP2-reactive cytotoxic T lymphocytes. Int J Cancer. 2001 Nov;94(4):540-4. DOI:10.1002/ijc.1508
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