ChemicalBook--->CAS DataBase List--->160969-03-9

160969-03-9

160969-03-9 Structure

160969-03-9 Structure
IdentificationBack Directory
[Name]

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate
[CAS]

160969-03-9
[Synonyms]

Silodosin Intermediate 1
2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate
2-[2-(2,2,2-trifluoroethoxy)phenoxy]-ethanol-1-Methanesulfonate
Ethanol,2-[2-(2,2,2-trifluoroethoxy)phenoxy]-, 1-Methanesulfonate
[EINECS(EC#)]

801-482-2
[Molecular Formula]

C11H13F3O5S
[MDL Number]

MFCD16038209
[MOL File]

160969-03-9.mol
[Molecular Weight]

314.28
Chemical PropertiesBack Directory
[Melting point ]

52.0 to 56.0 °C
[Boiling point ]

396.4±42.0 °C(Predicted)
[density ]

1.362
[storage temp. ]

2-8°C
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

Solid
[color ]

White to Off-White
[InChI]

InChI=1S/C11H13F3O5S/c1-20(15,16)19-7-6-17-9-4-2-3-5-10(9)18-8-11(12,13)14/h2-5H,6-8H2,1H3
[InChIKey]

HOJMCBMXHWZNKX-UHFFFAOYSA-N
[SMILES]

C(OS(C)(=O)=O)COC1=CC=CC=C1OCC(F)(F)F
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319
[Precautionary statements ]

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
[HS Code ]

2909.30.6000
Hazard InformationBack Directory
[Uses]

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl Methanesulfonate is an intermediate of Silodosin (S465000) which is an α1a-adrenoceptor antagonist and used in the treatment of benign prostatic hypertophy.
[Synthesis]

Anhydrous AlCl3 ( 165 g, 1 .24 mol) and 200 mL of anhydrous dichloromethane were mixed, cooled to -5 ℃ under nitrogen protection, methane sulfonyl chloride was added dropwise with stirring, and then stirred at room temperature for 30 min after the dropwis
Spectrum DetailBack Directory
[Spectrum Detail]

2-[2-(2,2,2-Trifluoroethoxy)phenoxy]ethyl methanesulfonate(160969-03-9)1HNMR
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