| Identification | Back Directory | [Name]
(±)-BAY-1251152 | [CAS]
1610358-53-6 | [Synonyms]
bay15251152
(±)-Enitociclib
2-Pyridinamine, 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[(S-methylsulfonimidoyl)methyl]-2-pyridinyl]-
((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanone | [Molecular Formula]
C19H18F2N4O2S | [MOL File]
1610358-53-6.mol | [Molecular Weight]
404.43 |
| Chemical Properties | Back Directory | [Boiling point ]
494.2±55.0 °C(Predicted) | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:50.0(Max Conc. mg/mL);123.63(Max Conc. mM) | [form ]
A solid | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
(±)-Enitociclib ((±)-BAY-1251152) is a racemic mixture of BAY-1251152. BAY-1251152 is a potent and highly selective PTEF/CDK9 inhibitor. BAY-1251152 can be used in the study of acute myelogenous leukemia and double-hit diffuse large B-cell lymphoma[1][2]. | [storage]
Store at -20°C | [References]
[1] Byrne M, et al. Phase I study of the PTEFb inhibitor BAY 1251152 in patients with acute myelogenous leukemia. Blood, 2018, 132: 4055.
[2] Lücking U, et al. Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer. J Med Chem. 2021 Aug 12;64(15):11651-11674. DOI:10.1021/acs.jmedchem.1c01000 |
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ChemShuttle, Inc.
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www.jiehuapharma.com/ |
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