| Identification | Back Directory | [Name]
3-Pyridinemethanol, 6-[(3-aminopropyl)amino]-, 1-oxide, hydrochloride (1:1) | [CAS]
1610362-93-0 | [Synonyms]
APAHMPO
APA-H-MPO
APA H MPO
3-Pyridinemethanol, 6-[(3-aminopropyl)amino]-, 1-oxide, hydrochloride (1:1) | [Molecular Formula]
C9H16ClN3O2 | [MOL File]
1610362-93-0.mol | [Molecular Weight]
233.7 |
| Hazard Information | Back Directory | [Description]
APA-H-MPO is an inhibitor of PCAF bromodomaiTat-AcK50 association. | [Uses]
APA-H-MPO hydrochloride is an inhibitor of PCAF bromodomain/Tat-AcK50 interaction with potential for anti-HIV/AIDS. APA-H-MPO hydrochloride can effectively inhibit the binding of PCAF bromodomain to Tat-AcK50. APA-H-MPO hydrochloride showed low cytotoxicity in preliminary cell studies. APA-H-MPO hydrochloride is considered a potential candidate for a promising inhibitory strategy targeting the host cell protein PCAF BRD to block HIV replication[1]. | [References]
[1] Fluorescence polarization for the evaluation of small-molecule inhibitors of PCAF BRD/Tat-AcK50 association DOI:10.1002/cmdc.201300499 |
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