| Identification | Back Directory | [Name]
2-Pyridinamine, 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[[[S(S)]-S-methylsulfonimidoyl]methyl]-2-pyridinyl]- | [CAS]
1610408-97-3 | [Synonyms]
VIP152
(S)-Enitociclib
2-Pyridinamine, 5-fluoro-4-(4-fluoro-2-methoxyphenyl)-N-[4-[[[S(S)]-S-methylsulfonimidoyl]methyl]-2-pyridinyl]- | [Molecular Formula]
C19H18F2N4O2S | [MOL File]
1610408-97-3.mol | [Molecular Weight]
404.44 |
| Hazard Information | Back Directory | [Uses]
Enitociclib (VIP152; BAY-1251152) is a selective CDK9 inhibitor. Known for its unique benzyl sulfoxide moiety, VIP152 has demonstrated promising efficacy and tolerability both in vitro and in vivo, including in mouse and rat xenograft models via weekly intravenous infusions Highly effective and well tolerated. VIP152 shows promising long-term single-agent inhibitory activity against double-click refractory diffuse large B-cell lymphoma[1]. | [References]
[1] Lücking U, et al. Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer. J Med Chem. 2021 Aug 12;64(15):11651-11674. DOI:10.1021/acs.jmedchem.1c01000 |
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