| Identification | Back Directory | [Name]
EpiMedokoreanin B | [CAS]
161068-53-7 | [Synonyms]
IcariinImpurity9
EpiMedokoreanin B
Icariin Impurity 8
2-[3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-[3,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-8-(3-methyl-2-buten-1-yl)- | [Molecular Formula]
C25H26O6 | [MDL Number]
MFCD26406172 | [MOL File]
161068-53-7.mol | [Molecular Weight]
422.47 |
| Chemical Properties | Back Directory | [Boiling point ]
665.9±55.0 °C(Predicted) | [density ]
1.301±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
6.61±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation[1][2][3]. | [in vivo]
Epimedokoreanin B (20 mg/kg; p.o; thrice a week; for 17 days) inhibits tumor growth in an LM8 tumor-bearing murine model[4]. | Animal Model: | Female C3H mice (8-10 weeks old) injected with LM8 cells[4] | | Dosage: | 20 mg/kg | | Administration: | Oral administration; thrice a week; for 17 days | | Result: | Inhibited tumor growth. |
| [References]
[1] Huaran Zhang, et al. Flavonoids from the leaves of Epimedium Koreanum Nakai and their potential cytotoxic activities. Nat Prod Res. 2020 May;34(9):1256-1263. DOI:10.1080/14786419.2018.1560283
[2] Hao Zheng, et al. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated paraptosis accompanied by autophagosome accumulation. Chem Biol Interact. 2022 Oct 1;366:110125. DOI:10.1016/j.cbi.2022.110125
[3] T Kariu, et al. Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenyl flavonoids. J Periodontal Res. 2017 Feb;52(1):89-96. DOI:10.1111/jre.12372
[4] Cheng Pan , et al. Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment. Front Pharmacol. 2020 Mar 18;11:262. DOI:10.3389/fphar.2020.00262 |
|
| Company Name: |
BioBioPha Co., Ltd.
|
| Tel: |
0871-65217109 13211707573; |
| Website: |
http://www.biobiopha.com |
|