| Identification | Back Directory | [Name]
N-cyclopropene-L-Lysine | [CAS]
1610703-09-7 | [Synonyms]
N-cyclopropene-L-Lysine
cyclopropene – L - Lysine (CP)
Click Amino Acid / cyclopropene – L - Lysine (CP)
L-Lysine, N6-[[(2-methyl-2-cyclopropen-1-yl)methoxy]carbonyl]- | [Molecular Formula]
C12H20N2O4 | [MOL File]
1610703-09-7.mol | [Molecular Weight]
256.3 |
| Chemical Properties | Back Directory | [Boiling point ]
452.1±40.0 °C(Predicted) | [density ]
1.208±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.53±0.24(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CypK (N-Cyclopropene-L-Lysine), a cyclopropene derivative of lysine, is efficiently incorporated into antibodies through genetic-code expansion. CypK is a minimal bioorthogonal handle for the creation of stable therapeutic protein conjugates[1][2]. | [References]
[1] Oller-Salvia B. Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction. J Vis Exp. 2018 Sep 14;(139):58066. DOI:10.3791/58066
[2] Oller-Salvia B, et, al. Rapid and Efficient Generation of Stable Antibody-Drug Conjugates via an Encoded Cyclopropene and an Inverse-Electron-Demand Diels-Alder Reaction. Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2831-2834. DOI:10.1002/anie.201712370 |
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