| Identification | Back Directory | [Name]
CARBAMIC ACID, (5-NITRO-2-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER | [CAS]
161117-88-0 | [Synonyms]
tert-butyl 5-nitropyridin-2-ylcarbaMate
tert-butyl N-(5-nitro-2-pyridyl)carbamate
tert-butyl N-(5-nitropyridin-2-yl)carbamate
N-(5-nitro-2-pyridinyl)carbamic acid tert-butyl ester
CARBAMIC ACID, (5-NITRO-2-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER
Carbamic acid, N-(5-nitro-2-pyridinyl)-, 1,1-dimethylethyl ester | [Molecular Formula]
C10H13N3O4 | [MDL Number]
MFCD11977408 | [MOL File]
161117-88-0.mol | [Molecular Weight]
239.23 |
| Chemical Properties | Back Directory | [Boiling point ]
325.2±27.0 °C(Predicted) | [density ]
1.303±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
11.35±0.70(Predicted) | [Appearance]
Light yellow to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
5-Nitropyridin-2-amine (1 eq.), di-tert-butyl dicarbonate (1.2 eq.) and 4-dimethylaminopyridine (0.2 eq.) were added to a reaction vial under nitrogen protection. Dichloromethane was added as solvent at room temperature and the reaction mixture was stirred overnight. Upon completion of the reaction, ethyl acetate was added to the crude product, the precipitate was collected by filtration and washed with ethyl acetate to afford the target product (5-nitropyridin-2-yl)carbamic acid tert-butyl ester. It was analyzed by HPLC-MS (Method A): retention time (Rt) = 2.88 min, m/z of [M + H]+: 240. 80% yield. | [References]
[1] Patent: WO2016/120808, 2016, A1. Location in patent: Page/Page column 103; 104
[2] Patent: EP2314593, 2016, B1. Location in patent: Paragraph 0132
[3] Patent: WO2015/131080, 2015, A1. Location in patent: Paragraph 001167; 001168
[4] Patent: US2010/249099, 2010, A1. Location in patent: Page/Page column 96-97
[5] Patent: US2011/9405, 2011, A1. Location in patent: Page/Page column 54 |
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