| Identification | Back Directory | [Name]
3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester | [CAS]
161187-57-1 | [Synonyms]
αGlucosidaseIN23
α-Glucosidase-IN-23
α-Glucosidase-IN-23, 10 mM in DMSO
3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3,5-diethyl ester | [Molecular Formula]
C20H23NO6 | [MOL File]
161187-57-1.mol | [Molecular Weight]
373.4 |
| Hazard Information | Back Directory | [Uses]
α-Glucosidase-IN-23 is an orally active α-Glucosidase inhibitor. α-Glucosidase-IN-23 decreases blood glucose by a-glucosidase inhibition with an IC50 value of 4.48 μM. α-Glucosidase-IN-23 can be used for the research of diabetes[1]. | [in vivo]
α-Glucosidase-IN-23 (oral; 0.2 mmol/kg/day) only inhibits a-glucosidase in mice[1].
| Animal Model: | Mice[1] | | Dosage: | 0.2 mmol/kg | | Administration: | Oral; 0.2 mmol/kg/day | | Result: | | Cmax (nmol/mL) | Tmax (h) | T1/2(h) | AUC (ng/h/mL) | | 10.11 ± 1.17 | 0.8 ± 0.0 | 1.90 ± 1.04 | 36.7 ± 2.23 |
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| [References]
[1] Peter A Sidhom, et al. Mechanistic Insight of Synthesized 1,4-Dihydropyridines as an Antidiabetic Sword against Reactive Oxygen Species. J Med Chem. 2023 Jan 12;66(1):991-1010. DOI:10.1021/acs.jmedchem.2c01818 |
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