| Hazard Information | Back Directory | [Description]
CPI-7c is a unique small-molecule inhibitor of MDM2. CPI-7c inhibits MDM2-p53 interaction and promotes MDM2 degradation. CPI-7c binds to both RING and N-terminal domains of MDM2 to promote its ubiquitin-mediated degradation and p53 stabilization. | [Uses]
Antiproliferative agent-61 is a synthetic β-carlinyl chalcone with significant antiproliferative activity. Antiproliferative agent-61 showed significant effects in a range of solid tumor cell lines, with the most prominent effects in breast cancer. Antiproliferative agent-61 showed IC50 values of 2.25 and 3.29 μM in the human breast cancer MCF-7 cell line. Antiproliferative agent-61 significantly induced DNA fragmentation and apoptosis in breast cancer cells. Antiproliferative agent-61 inhibited the interaction of MDM2 with p53 and promoted the degradation of MDM2[1]. | [References]
[1] Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells |
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