| Identification | Back Directory | [Name]
Niraparib tosylate | [CAS]
1613220-15-7 | [Synonyms]
Niraparib TOS H2O
Niraparib tosylate hydrate
Niraparib TsOH salt hydrate
Nilapani toluene monohydrate
Niraparib tosylate monohyrate
MK-4827, Niraparib TsOH salt hydrate
Niraparib Tosylate Monohydrate (API)
(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 4-methylbenzenesulfonate hydrate | [Molecular Formula]
C26H28N4O4S | [MOL File]
1613220-15-7.mol | [Molecular Weight]
492.59 |
| Chemical Properties | Back Directory | [solubility ]
DMSO: ~64 mg/mL (~199.8 mM)；Ethanol: ~64 mg/mL | [form ]
Solid | [color ]
White to off-white | [InChIKey]
LCPFHXWLJMNKNC-XOIICWPPNA-N | [SMILES]
S(C1C=CC(C)=CC=1)(O)(=O)=O.C(C1=CC=CC2=CN(C3C=CC([C@H]4CNCCC4)=CC=3)N=C12)(=O)N |&1:23,r| |
| Hazard Information | Back Directory | [Uses]
Niraparib tosylate hydrate is a sulfonic acid organic compound that can be used as a pharmaceutical intermediate. | [Mechanism of action]
Niraparib tosylate is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells.
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