| Identification | Back Directory | [Name]
(±)-1-Isopropyl-d7-amino-3-(1-naphthyloxy)-2-propanol hydrochloride | [CAS]
1613439-56-7 | [Synonyms]
D7-Propranolol hydrochloride
(±)-Propranolol-(isopropyl-d7) hydrochloride
(±)-1-Isopropyl-d7-amino-3-(1-naphthyloxy)-2-propanol hydrochloride | [Molecular Formula]
C16H15ClD7NO2 | [MDL Number]
MFCD11983489 | [MOL File]
1613439-56-7.mol | [Molecular Weight]
302.848 |
| Hazard Information | Back Directory | [Uses]
Propranolol-d7 (hydrochloride) is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1]. Propranolol hydrochloride inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM[2]. Propranolol hydrochloride is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[3]. | [IC 50]
β adrenergic receptor | [storage]
Store at -20°C | [References]
[1] Galandrin S, et al. Distinct signaling profiles of beta1 and beta2 adrenergic receptor ligands toward adenylyl cyclase and mitogen-activated protein kinase reveals the pluridimensionality of efficacy. Mol Pharmacol. 2006 Nov;70(5):1575-84. DOI:10.1124/mol.106.026716
[2] Briley M, et al. Evidence against beta-adrenoceptor blocking activity of diltiazem, a drug with calcium antagonist properties. Br J Pharmacol. 1980 Aug;69(4):669-73. DOI:10.1111/j.1476-5381.1980.tb07920.x
[3] Al-Majed AA, et al. Propranolol. Profiles Drug Subst Excip Relat Methodol. 2017;42:287-338. DOI:10.1016/bs.podrm.2017.02.006 |
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