| Identification | Back Directory | [Name]
Tyrosinase-IN-35 | [CAS]
1613467-47-2 | [Synonyms]
Tyrosinase-IN-35
Hydrazinecarbothioamide, 2-[[3-(4-hydroxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylene]-, (2Z)- | [Molecular Formula]
C17H15N5OS | [MOL File]
1613467-47-2.mol | [Molecular Weight]
337.4 |
| Chemical Properties | Back Directory | [Boiling point ]
576.583±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.358±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
8.508±0.15(predicted) |
| Hazard Information | Back Directory | [Uses]
Tyrosinase-IN-35 (compound 6g) is a human tyrosinase inhibitor (IC50: 2.09 μM), which is more potent than Kojic Acid (HY-W050154) (IC50: 16.38 μM). Tyrosinase-IN-35 can reduce the melanin content of melanoma B16F10 cells in vitro at doses of 4 μM and 8 μM[1]. | [References]
[1] Kinetic studies, molecular docking, and antioxidant activity of novel 1,3-diphenyl pyrazole-thiosemicarbazone with anti-tyrosinase and anti-melanogenesis properties |
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